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COVID-19 Corona Virus Disease is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 . This new virus and disease were unknown before the outbreak began in Wuhan, China in December-2019. The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, and talking. The droplets usually fall to the ground or onto surfaces rather than remaining in the air over long distances. People may also become infected by touching a contaminated surface and then touching their face. On surfaces, the amount of virus declines over time until it is insufficient to remain infectious, but it may be detected for hours or days. It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease. ImCoV-AgTM COVID-19 Antigen Rapid test device has two pre-coated lines, “C” Control line, “T” Test line on the surface of the nitrocellulose membrane. Both the control line and test line in the result window are not visible before applying any specimens. Mouse monoclonal anti- SARS-CoV-2 antibody is coated on the test line region and Goat anti Mouse IgG antibody is coated on the control line region. Mouse monoclonal anti-SARS-CoV-2 and Mouse IgG antibody conjugated with color particles are used as detectors for SARS-CoV-2 antigen device. During the test, SARS-CoV-2 antigen in the specimen interacts with monoclonal anti-SARS-CoV-2 antibody conjugated with color particles making antigen-antibody color particle complex. This complex migrates on the membrane via capillary action until the test line, where it will be captured by the mouse monoclonal anti-SARS-CoV-2 antibody. A colored test line would be visible in the result window if SARS-CoV-2 antigens are present in the specimen. The intensity of colored test line will vary depending upon the amount of SARS-CoV-2 antigen present in the specimen. If SARS-CoV-2 antigens are not present in the specimen, then no color appears in the test line. The control line is used for procedural control and should always appear if the test procedure is performed properly, and the test reagents of the control line are working.